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KPNA1 and H2BC21
Data Source:
HPRD
(in vitro)
KPNA1
H2BC21
Description
karyopherin subunit alpha 1
H2B clustered histone 21
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Postsynaptic Density
Dendrite
Host Cell
Glutamatergic Synapse
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Nuclear Import Signal Receptor Activity
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of DNA Recombination
Apoptotic DNA Fragmentation
NLS-bearing Protein Import Into Nucleus
Skeletal Muscle Satellite Cell Proliferation
Satellite Cell Activation Involved In Skeletal Muscle Regeneration
Modulation By Virus Of Host Cellular Process
Regulation Of Apoptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Intracellular Transport Of Virus
Postsynapse To Nucleus Signaling Pathway
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
ISG15 antiviral mechanism
Apoptosis induced DNA fragmentation
Integration of provirus
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Vpr-mediated nuclear import of PICs
Inhibition of nitric oxide production
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Calcium levels (
20705733
)
LDL cholesterol (
30275531
)
LDL cholesterol levels (
28334899
)
Mean corpuscular hemoglobin (
32888494
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Interacting Genes
45 interacting genes:
ANP32A
ANP32B
ARNT
BCAR3
CDKN1B
CLK4
CRADD
CSE1L
ELAVL1
EPAS1
FOSL1
GOPC
GTF2IRD1
H2BC21
H3-4
HDAC6
HIF1A
IL1RAP
KPNB1
LEF1
LINC01554
LMNB1
LMO4
MACROD1
MDM2
NMNAT1
NOSIP
NUP50
NUP54
NUP62
ORC4
PAX5
PKM
POLR3C
RAG1
RANBP2
RUNX1T1
SENP2
SKP2
SRP19
STAT1
STAT3
TAF9
UBR5
USP1
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
Entrez ID
3836
8349
HPRD ID
02819
03494
Ensembl ID
ENSG00000114030
ENSG00000184678
Uniprot IDs
B3KXZ2
P52294
Q16778
PDB IDs
2JDQ
3TJ3
4B18
6WX9
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
Enriched GO Terms of Interacting Partners
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