PTGIR and PDE6D

Data Source:
HPRD (in vivo)

		PTGIR	PDE6D
Description		prostaglandin I2 receptor	phosphodiesterase 6D
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		5739	5147
HPRD ID		08959	04056
Ensembl ID		ENSG00000160013	ENSG00000156973
Uniprot IDs		P43119	B8ZZK5 O43924 Q6IB24
PDB IDs			1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
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