PTGER4 and RNF220

Data Source:
BioGRID (two hybrid)

		PTGER4	RNF220
Description		prostaglandin E receptor 4	ring finger protein 220
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytoplasm
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)	Chronic obstructive pulmonary disease ( 30804561) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Interleukin-6 levels ( 22205395) Resting heart rate ( 29769521 27798624)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	7 interacting genes: GOPC PTGER4 SIN3B UBE2D2 UBE2D3 UBE2L3 USP7
Entrez ID		5734	55182
HPRD ID		03350	13336
Ensembl ID		ENSG00000171522	ENSG00000187147
Uniprot IDs		A0PJF5 P35408	Q5VTB9
PDB IDs		5YHL 5YWY
Enriched GO Terms of Interacting Partners?
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