RNF220 and SIN3B

Data Source:
BioGRID (enzymatic study)

		RNF220	SIN3B
Description		ring finger protein 220	SIN3 transcription regulator family member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Histone Deacetylase Complex Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Lipid Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Interleukin-6 levels ( 22205395) Resting heart rate ( 29769521 27798624)
Interacting Genes		7 interacting genes: GOPC PTGER4 SIN3B UBE2D2 UBE2D3 UBE2L3 USP7	20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16
Entrez ID		55182	23309
HPRD ID		13336	09691
Ensembl ID		ENSG00000187147	ENSG00000127511
Uniprot IDs		Q5VTB9	B7Z392 M0QYC5 O75182
PDB IDs
Enriched GO Terms of Interacting Partners?
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