PTGER4 and ACY3

Data Source:
BioGRID (two hybrid)

		PTGER4	ACY3
Description		prostaglandin E receptor 4	aminoacylase 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytosol Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Xenobiotic Metabolic Process Biological_process Viral Process
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Aflatoxin activation and detoxification
Drugs		Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)	Serum metabolite levels ( 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	21 interacting genes: AAMDC ARF5 ASPA CYSRT1 DDIT4L GORASP2 INCA1 KRTAP10-3 KRTAP10-8 KRTAP15-1 KRTAP26-1 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 PTGER4 RARG RRAS
Entrez ID		5734	91703
HPRD ID		03350	12422
Ensembl ID		ENSG00000171522	ENSG00000132744
Uniprot IDs		A0PJF5 P35408	A0A024R5L2 Q96HD9
PDB IDs		5YHL 5YWY
Enriched GO Terms of Interacting Partners?
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