PTGER4 and PRDX1

Data Source:
BioGRID (two hybrid)

		PTGER4	PRDX1
Description		prostaglandin E receptor 4	peroxiredoxin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Cadherin Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Cellular Response To Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Dinoprostone Misoprostol Limaprost Castor oil Grapiprant	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)	Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	29 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		5734	5052
HPRD ID		03350	01458
Ensembl ID		ENSG00000171522	ENSG00000117450
Uniprot IDs		A0PJF5 P35408	A0A384NPQ2 Q06830
PDB IDs		5YHL 5YWY	2RII 3HY2 4XCS
Enriched GO Terms of Interacting Partners?
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