PTGER4 and SLBP

Data Source:
BioGRID (two hybrid)

		PTGER4	SLBP
Description		prostaglandin E receptor 4	stem-loop binding protein
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Export From Nucleus Histone MRNA Metabolic Process MRNA Transport
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs		Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 25673412) Hip minimal joint space width ( 27701424) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	8 interacting genes: CDK4 CDK6 DCAF11 ERI1 LSM10 PTGER4 USP8 ZNF473
Entrez ID		5734	7884
HPRD ID		03350	03884
Ensembl ID		ENSG00000171522	ENSG00000163950
Uniprot IDs		A0PJF5 P35408	B3KSC5 B3KST9 B4DUW7 E7EUV9 Q14493 Q53XR2
PDB IDs		5YHL 5YWY	2KJM 4L8R 4QOZ
Enriched GO Terms of Interacting Partners?
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