TTK and CDCA8

Data Source:
BioGRID (enzymatic study)

		TTK	CDCA8
Description		TTK protein kinase	cell division cycle associated 8
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GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Spindle Membrane	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinetochore Binding	Protein Binding
	Biological Process	Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Female Meiosis Chromosome Segregation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Meiotic Spindle Assembly Checkpoint Protein Localization To Kinetochore Protein Autophosphorylation Chromosome Separation Protein Localization To Meiotic Spindle Midzone	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16	26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277
Entrez ID		7272	55143
HPRD ID		04973	13017
Ensembl ID		ENSG00000112742	ENSG00000134690
Uniprot IDs		P33981	Q53HL2
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND	2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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