TTK and AZU1

Data Source:
HPRD (in vivo)

		TTK	AZU1
Description		TTK protein kinase	azurocidin 1
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Spindle Membrane	Extracellular Region Extracellular Space Extrinsic Component Of Membrane Azurophil Granule Membrane Azurophil Granule Lumen Azurophil Granule Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinetochore Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Toxic Substance Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Female Meiosis Chromosome Segregation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Meiotic Spindle Assembly Checkpoint Protein Localization To Kinetochore Protein Autophosphorylation Chromosome Separation Protein Localization To Meiotic Spindle Midzone	Microglial Cell Activation Proteolysis Inflammatory Response Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Glial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Antimicrobial Humoral Response Fractalkine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Calcium-mediated Signaling Using Intracellular Calcium Source Monocyte Activation Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Neutrophil Degranulation Cellular Extravasation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Macrophage Chemotaxis Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Induction Of Positive Chemotaxis Defense Response To Virus Cell Chemotaxis Protein Kinase C Signaling Neutrophil-mediated Killing Of Bacterium
Pathways			Neutrophil degranulation
Drugs		Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)	Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16	2 interacting genes: CLEC4G TTK
Entrez ID		7272	566
HPRD ID		04973	01221
Ensembl ID		ENSG00000112742	ENSG00000172232
Uniprot IDs		P33981	P20160
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND	1A7S 1AE5 1FY1 1FY3
Enriched GO Terms of Interacting Partners?
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