EXOSC5 and HAMP

Data Source:
BioGRID (affinity chromatography technology)

		EXOSC5	HAMP
Description		exosome component 5	hepcidin antimicrobial peptide
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Extracellular Region Extracellular Space Nucleus Intercalated Disc Apical Cortex
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Hormone Activity Copper Ion Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Cell Homeostasis Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Receptor Signaling Pathway Via JAK-STAT Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Positive Regulation Of Macrophage Activation Response To Ethanol Negative Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS			Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414)
Interacting Genes		80 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HBS1L HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	4 interacting genes: CKAP4 GLP1R SLC40A1 VKORC1
Entrez ID		56915	57817
HPRD ID		16222	05925
Ensembl ID		ENSG00000077348	ENSG00000105697
Uniprot IDs		Q9NQT4	P81172
PDB IDs		2NN6 6D6Q 6D6R 6H25	1M4E 1M4F 2KEF 3H0T 4QAE 6WBV
Enriched GO Terms of Interacting Partners?
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