EXOSC5 and PA2G4

Data Source:
HPRD (two hybrid)

		EXOSC5	PA2G4
Description		exosome component 5	proliferation-associated 2G4
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Extracellular Region Nucleus Nucleolus Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	RRNA Processing Regulation Of Translation Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Neutrophil degranulation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		80 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HBS1L HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	21 interacting genes: AR ATR ERBB3 ESR1 EXOSC5 HDAC2 HMGA1 HMGA2 HSPA4 IKBKG LIG4 MTOR PRKCA PRKCB PRKCG RB1 RNF20 SIN3A STUB1 SUMO4 TERF1
Entrez ID		56915	5036
HPRD ID		16222	03685
Ensembl ID		ENSG00000077348	ENSG00000170515
Uniprot IDs		Q9NQT4	A0A024RB85 Q9UQ80
PDB IDs		2NN6 6D6Q 6D6R 6H25	2Q8K 3J2I 6CHT 6LSR 6SXO 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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