EXOSC5 and ZNF792

Data Source:
BioGRID (two hybrid)

		EXOSC5	ZNF792
Description		exosome component 5	zinc finger protein 792
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Nucleus
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Transcription By RNA Polymerase II
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Generic Transcription Pathway
Drugs
Diseases
GWAS			Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		80 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HBS1L HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	55 interacting genes: AQP1 BACH2 CCDC125 CCNC DVL3 ELOA EXOSC5 FAM161A FBL FHL5 GAS8 GOLGA6L9 HNRNPK KCTD12 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 MCC MID2 MTUS2 PRPF31 RBMY1F RBMY1J RNF4 SSX2IP TBC1D26 TLE5 TRIM41 TXK UBC ZBTB24 ZNF250 ZNF275 ZNF286A ZNF408 ZNF473 ZNF48 ZNF497 ZNF526 ZNF552 ZNF581 ZNF639 ZNF648 ZNF655 ZNF668 ZNF71 ZNF835 ZNF837 ZRANB1
Entrez ID		56915	126375
HPRD ID		16222	13430
Ensembl ID		ENSG00000077348	ENSG00000180884
Uniprot IDs		Q9NQT4	Q3KQV3
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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