SERPINB6 and PROC

Data Source:
HPRD (in vitro)

		SERPINB6	PROC
Description		serpin family B member 6	protein C, inactivator of coagulation factors Va and VIIIa
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Sensory Perception Of Sound Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Cellular Response To Osmotic Stress	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Neutrophil degranulation Dissolution of Fibrin Clot	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases			Inherited thrombophilia
GWAS		Chronic lymphocytic leukemia ( 26956414) Crohn's disease ( 32581322)	Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		7 interacting genes: F10 F2 KLK2 PLAU PLG PROC SUMO2	15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		5269	5624
HPRD ID		01413	01466
Ensembl ID		ENSG00000124570	ENSG00000115718
Uniprot IDs		A0A024QZX3 A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237	P04070
PDB IDs			1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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