CP and LTF

Data Source:
HPRD (in vivo, in vitro)

		CP	LTF
Description		ceruloplasmin	lactotransferrin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleus Cytoplasm Early Endosome Plasma Membrane Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Recycling Endosome Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen
	Molecular Function	Ferroxidase Activity Copper Ion Binding Oxidoreductase Activity Chaperone Binding	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Copper Ion Transport Iron Ion Transport Cellular Iron Ion Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis	Ossification Regulation Of Cytokine Production Retina Homeostasis Innate Immune Response In Mucosa Proteolysis Iron Ion Transport Humoral Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Other Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATPase Activity Siderophore-dependent Iron Import Into Cell Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Disruption In Other Organism Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport	Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation
Drugs		Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form	3h-Indole-5,6-Diol Lauric acid Nitrilotriacetic acid alpha-D-Fucopyranose Nimesulide (R)-Atenolol Parecoxib
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)	AIDS progression ( 21502085) Blood protein levels ( 29875488 28240269) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Inflammatory bowel disease ( 26192919) Macular thickness ( 30535121) Ulcerative colitis ( 26192919)
Interacting Genes		7 interacting genes: ATP7A BTRC GAST LTF MPO PLG PROC	11 interacting genes: CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC
Entrez ID		1356	4057
HPRD ID		00317	01028
Ensembl ID		ENSG00000047457	ENSG00000012223
Uniprot IDs		A5PL27 P00450	B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4
PDB IDs		1KCW 2J5W 4EJX 4ENZ	1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS
Enriched GO Terms of Interacting Partners?
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