PRNP and TSC22D4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRNP	TSC22D4
Description		prion protein	TSC22 domain family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Cell Surface Postsynaptic Density Inclusion Body Extrinsic Component Of Membrane Dendrite Anchored Component Of External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Postsynapse	Nucleus
	Molecular Function	Amyloid-beta Binding Protease Binding Copper Ion Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding Cuprous Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Learning Or Memory Long-term Memory Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Protein Destabilization Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Positive Regulation Of Protein Targeting To Membrane Modulation Of Age-related Behavioral Decline Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Negative Regulation Of Amyloid-beta Formation Regulation Of Intracellular Calcium Activated Chloride Channel Activity Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways		NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Tetracycline Copper
Diseases		Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (sporadic) ( 32949544 25918841) Creutzfeldt-Jakob disease (variant) ( 22137330) KANNO antigen negativity ( 31020675) Platelet aggregation ( 20526338) Prion diseases ( 22210626) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		96 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 ATIC BAG6 BAZ2B C7orf50 CAV1 CCDC149 CCR1 CIRBP CLSTN1 CLU CNP CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FHL1 FZD7 GRB2 HAX1 HSPA5 HSPD1 IER3 KIAA1191 KIFAP3 L1CAM LMNA LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 WDR61 ZFYVE28 ZKSCAN8 ZNF408 ZNF740	63 interacting genes: ABLIM1 AIFM1 APIP ARHGAP9 BLZF1 CBX8 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU CTNNAL1 ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO1 LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP MYO15B NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PCDH17 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TRIM55 TRIM63 TSC22D1 TSPOAP1 UBLCP1 VBP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		5621	81628
HPRD ID		01453	18231
Ensembl ID		ENSG00000171867	ENSG00000166925
Uniprot IDs		F7VJQ1 P04156 Q53YK7	B4DKI8 Q9Y3Q8
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR
Enriched GO Terms of Interacting Partners?
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