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PRNP and HSPA5
Data Source:
HPRD
(in vivo)
PRNP
HSPA5
Description
prion protein
heat shock protein family A (Hsp70) member 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Surface
Postsynaptic Density
Inclusion Body
Extrinsic Component Of Membrane
Dendrite
Anchored Component Of External Side Of Plasma Membrane
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Membrane Raft
Extracellular Exosome
Postsynapse
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Amyloid-beta Binding
Protease Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Glycosaminoglycan Binding
Microtubule Binding
Tubulin Binding
Aspartic-type Endopeptidase Inhibitor Activity
Type 5 Metabotropic Glutamate Receptor Binding
Type 8 Metabotropic Glutamate Receptor Binding
Signaling Receptor Activity
Identical Protein Binding
Protein-containing Complex Binding
Cuprous Ion Binding
Calcium Ion Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
Biological Process
Negative Regulation Of Protein Phosphorylation
Cellular Copper Ion Homeostasis
Response To Oxidative Stress
Cell Cycle Arrest
Learning Or Memory
Long-term Memory
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Protein Processing
Protein Destabilization
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-2 Production
Calcium-mediated Signaling Using Intracellular Calcium Source
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Activated T Cell Proliferation
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of T Cell Receptor Signaling Pathway
Protein Homooligomerization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Copper Ion
Positive Regulation Of Protein Targeting To Membrane
Modulation Of Age-related Behavioral Decline
Dendritic Spine Maintenance
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Amyloid-beta Formation
Regulation Of Intracellular Calcium Activated Chloride Channel Activity
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Regulation Of Calcium Ion Import Across Plasma Membrane
Neuron Projection Maintenance
Luteolysis
ER Overload Response
Positive Regulation Of Neuron Projection Development
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Neuron Differentiation
Positive Regulation Of Cell Migration
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Posttranslational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Cellular Response To Unfolded Protein
Protein Folding In Endoplasmic Reticulum
Maintenance Of Protein Localization In Endoplasmic Reticulum
Cellular Response To Drug
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Protein Refolding
Cellular Response To Glucose Starvation
Response To Cocaine
Negative Regulation Of Apoptotic Process
Chaperone Cofactor-dependent Protein Refolding
Neuron Apoptotic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Antibiotic
Cellular Response To Calcium Ion
Cellular Response To Manganese Ion
Cellular Response To CAMP
Cellular Response To Interleukin-4
Cellular Response To Gamma Radiation
Stress Response To Metal Ion
Toxin Transport
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Response To Methamphetamine Hydrochloride
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
NCAM1 interactions
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Tetracycline
Copper
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
GWAS
Creutzfeldt-Jakob disease (
19081515
)
Creutzfeldt-Jakob disease (sporadic) (
32949544
25918841
)
Creutzfeldt-Jakob disease (variant) (
22137330
)
KANNO antigen negativity (
31020675
)
Platelet aggregation (
20526338
)
Prion diseases (
22210626
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI (smoking interaction) (
28443625
)
Refractive error (
32231278
)
Interacting Genes
96 interacting genes:
ABT1
ADAM23
ADAP2
ADRB2
AGO1
AIFM3
APBB1
APLP1
APLP2
APOE
ARHGAP15
ATIC
BAG6
BAZ2B
C7orf50
CAV1
CCDC149
CCR1
CIRBP
CLSTN1
CLU
CNP
CNTN1
CRYAB
CSN3
CSNK2A1
CSNK2A2
CSNK2B
CWC15
DDX47
DNM1
DOCK7
DPP6
DYRK3
ERI3
F2RL1
FAM27E3
FBLN5
FBXO45
FGF13
FHL1
FZD7
GRB2
HAX1
HSPA5
HSPD1
IER3
KIAA1191
KIFAP3
L1CAM
LMNA
LSAMP
MAG
MARK4
MMADHC
MOG
MTG1
NCAM1
NCAM2
NECTIN1
NHP2
NIPSNAP2
NOB1
OPCML
P4HB
PDE4DIP
PLG
PPFIBP2
PPP1R14A
PSMA3
PSMB5
PTAFR
PTRH1
PYM1
RBM22
RNPC3
RPL41
SCNM1
SEC31A
SPARCL1
STARD5
STIP1
SURF2
TBPL1
TMEM237
TRIM15
TSC22D4
TSLP
TYMSOS
UTP4
WDR5
WDR61
ZFYVE28
ZKSCAN8
ZNF408
ZNF740
70 interacting genes:
A2M
APC
APOB
BAG3
BCAR1
CASP7
CPT1A
DDX24
DNAJC1
DNAJC10
DNAJC3
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
GRB2
GRIA1
HLA-C
HMGB1
HSPB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
OTUD3
PARK7
PAWR
PCSK7
PRNP
PSME3
PTPN11
PTPRF
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
YWHAB
Entrez ID
5621
3309
HPRD ID
01453
00682
Ensembl ID
ENSG00000171867
ENSG00000044574
Uniprot IDs
F7VJQ1
P04156
Q53YK7
P11021
V9HWB4
PDB IDs
1E1G
1E1J
1E1P
1E1S
1E1U
1E1W
1FKC
1FO7
1H0L
1HJM
1HJN
1I4M
1OEH
1OEI
1QLX
1QLZ
1QM0
1QM1
1QM2
1QM3
2IV4
2IV5
2IV6
2K1D
2KUN
2LBG
2LEJ
2LFT
2LSB
2LV1
2M8T
2OL9
2W9E
3HAF
3HAK
3HEQ
3HER
3HES
3HJ5
3HJX
3MD4
3MD5
3NHC
3NHD
3NVF
4DGI
4E1H
4E1I
4KML
4N9O
5L6R
5YJ4
5YJ5
6DU9
6LNI
6PQ5
6PQA
6SUZ
6SV2
6UUR
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
Enriched GO Terms of Interacting Partners
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