PCDHA4 and IGSF21

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PCDHA4	IGSF21
Description		protocadherin alpha 4	immunoglobin superfamily member 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation
Pathways
Drugs
Diseases
GWAS		Neutrophil count ( 27863252) Schizophrenia ( 28991256 29483656) Sum basophil neutrophil counts ( 27863252)	Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)
Interacting Genes		16 interacting genes: APLP1 CCDC90B EEF1A1 ERG28 GAPDH GDF9 IGSF21 LRIF1 RBM48 RELN SETDB1 SGTA TLE1 TP53 UBQLN1 UNC119	32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		56144	84966
HPRD ID		07322	11309
Ensembl ID		ENSG00000204967	ENSG00000117154
Uniprot IDs		Q59H34 Q9UN74	Q96ID5
PDB IDs
Enriched GO Terms of Interacting Partners?
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