MBP and PTAFR

Data Source:
BioGRID (two hybrid)

		MBP	PTAFR
Description		myelin basic protein	platelet activating factor receptor
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity Mitogen-activated Protein Kinase Binding
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Positive Regulation Of Cellular Extravasation Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Parturition Response To Symbiotic Bacterium Positive Regulation Of Phospholipase C Activity Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Transcytosis Positive Regulation Of Translation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Inositol Phosphate Biosynthetic Process Cellular Response To Gravity Cellular Response To CAMP Cellular Response To Fatty Acid Response To Dexamethasone Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Transcytosis Positive Regulation Of Maternal Process Involved In Parturition Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Cellular Response To 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling
Drugs			Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Blond vs. brown/black hair color ( 30531825)
Interacting Genes		81 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP MFSD3 PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SPATA24 TMEM120A TMX2 TYK2
Entrez ID		4155	5724
HPRD ID		01158	01422
Ensembl ID		ENSG00000197971	ENSG00000169403
Uniprot IDs		A0A024R384 P02686	A8K7N8 P25105
PDB IDs		1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL	2B0X
Enriched GO Terms of Interacting Partners?
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