LRIF1 and SPG7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRIF1	SPG7
Description		ligand dependent nuclear receptor interacting factor 1	SPG7 matrix AAA peptidase subunit, paraplegin
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Barr Body Nucleoplasm Nuclear Matrix Centriolar Satellite	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Permeability Transition Pore Complex
	Molecular Function	Protein Binding Retinoic Acid Receptor Binding	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Dosage Compensation By Inactivation Of X Chromosome	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Nervous System Development Mitochondrial Fusion Mitochondrial Protein Processing Cristae Formation Regulation Of Mitochondrial Membrane Permeability Protein-containing Complex Assembly Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways			Processing of SMDT1
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Bone mineral content ( 31790847) Intraocular pressure ( 30591961)	Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		144 interacting genes: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BANP BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX3 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRACR2A CRADD CRCP CRCT1 DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FHL2 FOSL2 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 H3-4 HAP1 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NOC2L NR3C1 NRBP1 NTAQ1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR1C POLR2C POLR3F PPARG PQBP1 PRKAB2 PRKAR2A PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SNU13 SPATA18 SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TDGF1 TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSEN15 TSPAN6 UBE2V2 UNC119 VIM VPS26C WDR62 WWC1 ZNF24 ZNF410	29 interacting genes: BDKRB2 CCNDBP1 CYSRT1 HNRNPK HSF2BP KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		55791	6687
HPRD ID		17975	04149
Ensembl ID		ENSG00000121931	ENSG00000197912
Uniprot IDs		Q5T3J3	A0A2R8Y632 Q9UQ90
PDB IDs			2QZ4
Enriched GO Terms of Interacting Partners?
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