SPG7 and HNRNPK

Data Source:
BioGRID (two hybrid, two hybrid)

		SPG7	HNRNPK
Description		SPG7 matrix AAA peptidase subunit, paraplegin	heterogeneous nuclear ribonucleoprotein K
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Permeability Transition Pore Complex	Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding	DNA Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding
	Biological Process	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Nervous System Development Mitochondrial Fusion Mitochondrial Protein Processing Cristae Formation Regulation Of Mitochondrial Membrane Permeability Protein-containing Complex Assembly Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II RNA Processing Signal Transduction Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Viral Process RNA Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Low-density Lipoprotein Receptor Activity
Pathways		Processing of SMDT1	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		29 interacting genes: BDKRB2 CCNDBP1 CYSRT1 HNRNPK HSF2BP KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28	220 interacting genes: ABI1 ABI2 ADRB2 ANKRD28 APBB1 APOBEC1 APOBEC3C AQP5 AURKA BTRC C6orf223 C6orf226 CBLB CCAR1 CCDC187 CCDC33 CDKN1A CEBPB CIRBP CMTM5 CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 DUX4 EIF3F ELAVL1 ETNK2 FBXL18 FBXO7 FBXW7 FOXD4L1 FOXD4L3 FYN GFI1B GRAP2 GRB2 GZMA GZMK H3-4 HBZ HCK HMGB1 HNRNPA0 HNRNPL HNRNPLL IRGC ITK ITSN2 KCTD8 KHDRBS1 KHDRBS2 KHDRBS3 KLF1 LYN MAP2K2 MAPK10 MARK4 MATR3 MDM2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MISP MRPL9 MYPOP NCK2 NEDD4 NOTO NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PGAP6 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 QKI RALY RAMAC RASAL3 RASD1 RBFOX2 RBM10 RBM14 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RNA18SN5 RNA28SN5 RNF4 RPH3AL RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TCF23 TERF2IP TH TLE5 TYK2 U2AF1 U2AF1L5 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF408 ZNF526 ZNF575 ZNF688 ZNF792 ZNRF2P1
Entrez ID		6687	3190
HPRD ID		04149	02834
Ensembl ID		ENSG00000197912	ENSG00000165119
Uniprot IDs		A0A2R8Y632 Q9UQ90	B4DUQ1 P61978
PDB IDs		2QZ4	1J5K 1KHM 1ZZI 1ZZJ 1ZZK
Enriched GO Terms of Interacting Partners?
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