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LRIF1 and RAP1B
Data Source:
BioGRID
(two hybrid)
LRIF1
RAP1B
Description
ligand dependent nuclear receptor interacting factor 1
RAP1B, member of RAS oncogene family
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Barr Body
Nucleoplasm
Nuclear Matrix
Centriolar Satellite
Lipid Droplet
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Azurophil Granule Membrane
Membrane Raft
Extracellular Exosome
Molecular Function
Protein Binding
Retinoic Acid Receptor Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein-containing Complex Binding
Biological Process
Regulation Of Transcription, DNA-templated
Dosage Compensation By Inactivation Of X Chromosome
Cell Population Proliferation
Response To Carbohydrate
Microvillus Assembly
Rap Protein Signal Transduction
Positive Regulation Of Integrin Activation
Cellular Response To Drug
Interleukin-12-mediated Signaling Pathway
Neutrophil Degranulation
Negative Regulation Of Calcium Ion-dependent Exocytosis
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Cellular Response To Gonadotropin-releasing Hormone
Regulation Of Cell Junction Assembly
Regulation Of Establishment Of Cell Polarity
Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Diseases
GWAS
Bone mineral content (
31790847
)
Intraocular pressure (
30591961
)
Femoral neck bone mineral density (
32239398
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
White blood cell count (
20139978
)
Interacting Genes
144 interacting genes:
AKR1C3
ANKRD24
ANXA1
ANXA7
APLP1
ARL3
ATF3
ATP1B1
BANP
BARD1
BMI1
BOC
BRD7
BRMS1
CALR
CBX1
CBX3
CBX5
CCDC106
CDC42
CDKN1A
CDKN2C
CETN3
CHD3
CKMT2
COX17
CPE
CRACR2A
CRADD
CRCP
CRCT1
DDIT4
EIF6
ESR1
ETHE1
FAS
FEZ1
FHL2
FOSL2
FXR1
GADD45G
GC
GIT1
GPRASP2
GSTM4
H3-4
HAP1
HLA-DQA1
HMGB1
HMOX2
HSPB1
HSPB3
HSPBP1
HSPE1
ID2
IMMT
KAT5
KAT7
KBTBD7
KCNE3
KLHL20
KLK10
LAMA4
LAMTOR5
MAD2L1BP
MLLT3
MNAT1
MOB4
MPHOSPH6
MRPS12
MRPS6
NACA
NOC2L
NR3C1
NRBP1
NTAQ1
PAEP
PAFAH1B3
PCDHA4
PDCD5
PFDN1
PFN1
PIAS4
PIN1
PLEKHA4
PNP
POLR1C
POLR2C
POLR3F
PPARG
PQBP1
PRKAB2
PRKAR2A
PRMT1
PSG9
PSMD11
PSMD2
PSPC1
RAB27A
RAP1B
RARA
RBM5
RCC1
RFC5
RHOH
RIT1
RNF10
RORA
RPA2
RPL37A
RPLP1
RRM1
S100A8
SAT1
SELENBP1
SERPINB9
SETDB1
SMN1
SNRPN
SNU13
SPATA18
SPG7
STX5
SULT1E1
SUPT4H1
SUV39H2
TAF1D
TDGF1
TGIF1
THRB
TK1
TRBV2
TRDMT1
TSC22D1
TSEN15
TSPAN6
UBE2V2
UNC119
VIM
VPS26C
WDR62
WWC1
ZNF24
ZNF410
30 interacting genes:
A2M
ALAS1
APLP1
APP
CCT7
CHGB
CSAD
DDAH2
FAF1
HRAS
KMT2B
LRIF1
MTUS2
PDHB
PKM
PRKACA
RAB7B
RALGDS
RAPGEF1
RASSF5
RGL2
RGS2
RPTOR
SDF4
SMURF2
TLE1
TP53
UNC119
ZDHHC17
ZNF135
Entrez ID
55791
5908
HPRD ID
17975
01546
Ensembl ID
ENSG00000121931
ENSG00000127314
Uniprot IDs
Q5T3J3
A0A024RB87
B7ZAY2
P61224
PDB IDs
3BRW
3CF6
4DXA
4HDO
4HDQ
4M8N
4MGI
4MGK
4MGY
4MGZ
4MH0
5KHO
6AXF
6BA6
6KYK
6OQ3
6OQ4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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