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PRKAR2A and EZR
Data Source:
HPRD
(in vivo)
PRKAR2A
EZR
Description
protein kinase cAMP-dependent type II regulatory subunit alpha
ezrin
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Focal Adhesion
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Plasma Membrane Raft
Extracellular Exosome
Ciliary Base
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Molecular Function
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Protein Domain Specific Binding
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Biological Process
Renal Water Homeostasis
Blood Coagulation
Regulation Of Protein Kinase A Signaling
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Regulation Of CAMP-mediated Signaling
Cellular Response To Glucagon Stimulus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
PKA activation
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog 'off' state
ROBO receptors bind AKAP5
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Drugs
GEM-231
Diseases
GWAS
Blood protein levels (
28240269
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Depressive symptom (depressed mood) (binary trait) (
31530331
)
Depressive symptom (depressed mood) (ordinal trait) (
31530331
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Morning person (
30696823
)
Resting heart rate (
27798624
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Interacting Genes
34 interacting genes:
AKAP1
AKAP10
AKAP11
AKAP12
AKAP13
AKAP14
AKAP3
AKAP4
AKAP5
AKAP6
AKAP7
AKAP8
AKAP9
ARFGEF2
CBFA2T3
CFTR
EZR
FOS
LRIF1
MAP2
MYCBPAP
NBEA
PJA2
PPP1CB
PRKX
RAB32
RET
RUNX1T1
RYR2
SCTR
SEMG2
SMAD3
SMAD4
WASF1
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
Entrez ID
5576
7430
HPRD ID
01484
00475
Ensembl ID
ENSG00000114302
ENSG00000092820
Uniprot IDs
A0A024R2W3
A0A0S2Z472
A8KAH7
P13861
P15311
PDB IDs
2IZX
2KYG
4ZP3
5H78
5XBY
1NI2
4RM8
4RM9
4RMA
Enriched GO Terms of Interacting Partners
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