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PRKACB and ARFGAP1
Data Source:
BioGRID
(two hybrid)
PRKACB
ARFGAP1
Description
protein kinase cAMP-activated catalytic subunit beta
ADP ribosylation factor GTPase activating protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Centrosome
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ciliary Base
Golgi Membrane
Cytosol
Synapse
Molecular Function
Magnesium Ion Binding
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
GTPase Activator Activity
Protein Binding
Metal Ion Binding
Biological Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Renal Water Homeostasis
Protein Phosphorylation
Signal Transduction
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Blood Coagulation
Protein Kinase A Signaling
Activation Of Protein Kinase A Activity
High-density Lipoprotein Particle Assembly
Negative Regulation Of Meiotic Cell Cycle
Regulation Of Protein Processing
Cellular Response To Glucagon Stimulus
Response To Clozapine
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Protein Transport
Regulation Of Endocytosis
Regulation Of ARF Protein Signal Transduction
IRE1-mediated Unfolded Protein Response
Positive Regulation Of GTPase Activity
Pathways
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of Adenylate Cyclase
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
RET signaling
HDL assembly
ROBO receptors bind AKAP5
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Clathrin-mediated endocytosis
Drugs
Phosphonothreonine
Fostamatinib
Diseases
GWAS
Breast cancer (male) (
23001122
)
Metabolite levels (
23823483
)
Interacting Genes
15 interacting genes:
ACVR1B
APPBP2
ARFGAP1
AVPI1
CSNK2A1
FBXO7
NGFR
PKIA
PKIB
RPL27A
RPS6
SPP1
TNP1
TNP2
TP73
34 interacting genes:
AGTR1
APOB
APOC3
APOE
APP
ARF1
ASB10
COPA
COPS5
CSNK1D
CYTH2
FOS
GABARAPL2
GRN
HRAS
KDELR1
KRTAP10-9
KRTAP3-2
KRTAP9-2
LRRK2
MAP1LC3B
MED27
PRKACB
RAB23
RABGAP1L
RASIP1
REEP5
RFC3
RGS2
RPL11
SMN1
TK1
TMED2
TRIM23
Entrez ID
5567
55738
HPRD ID
01482
06443
Ensembl ID
ENSG00000142875
ENSG00000101199
Uniprot IDs
A0A087WVC4
B1APF9
B1APG3
B2RB89
B7ZA00
P22694
Q53F62
Q8N6T3
PDB IDs
3DWD
3O47
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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