Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PRKACB and PKIA
Data Source:
HPRD
(in vitro)
PRKACB
PKIA
Description
protein kinase cAMP-activated catalytic subunit beta
cAMP-dependent protein kinase inhibitor alpha
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Centrosome
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ciliary Base
Nucleus
Cytoplasm
Molecular Function
Magnesium Ion Binding
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Renal Water Homeostasis
Protein Phosphorylation
Signal Transduction
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Blood Coagulation
Protein Kinase A Signaling
Activation Of Protein Kinase A Activity
High-density Lipoprotein Particle Assembly
Negative Regulation Of Meiotic Cell Cycle
Regulation Of Protein Processing
Cellular Response To Glucagon Stimulus
Response To Clozapine
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of Adenylate Cyclase
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
RET signaling
HDL assembly
ROBO receptors bind AKAP5
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
Drugs
Phosphonothreonine
Fostamatinib
3,5-Diiodotyrosine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Diseases
GWAS
Breast cancer (male) (
23001122
)
Metabolite levels (
23823483
)
Femoral neck bone mineral density (
22504420
)
Intraocular pressure (
29617998
31959993
)
Multiple sclerosis (
21833088
)
Optic disc size (
31809533
)
Systemic lupus erythematosus (
28714469
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Interacting Genes
15 interacting genes:
ACVR1B
APPBP2
ARFGAP1
AVPI1
CSNK2A1
FBXO7
NGFR
PKIA
PKIB
RPL27A
RPS6
SPP1
TNP1
TNP2
TP73
12 interacting genes:
AGFG1
CASP6
DYNLL1
DYNLL2
EGFR
JUNB
MRNIP
PRC1
PRKACA
PRKACB
PRKX
XPO1
Entrez ID
5567
5569
HPRD ID
01482
05828
Ensembl ID
ENSG00000142875
ENSG00000171033
Uniprot IDs
A0A087WVC4
B1APF9
B1APG3
B2RB89
B7ZA00
P22694
A0A024R7Y9
P61925
PDB IDs
1CMK
1JLU
1Q8T
1VEB
1XH4
1XH5
1XH6
1XH7
1XH8
1XH9
1XHA
1YDR
2C1A
2C1B
2F7E
2GNI
2JDS
2JDT
2JDV
2L1L
2UVX
2UVY
2UVZ
2UW0
2UW3
2UW4
2UW5
2UW6
2UW7
2UW8
2VNW
2VNY
2VO0
2VO3
2VO6
2VO7
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
3WYG
3X2U
3X2V
3X2W
4AXA
4IAC
4IAD
4IAF
4IAI
4IAK
4IAY
4IAZ
4IB0
4IB1
4IB3
4IE9
4IJ9
4O21
4O22
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
4Z83
4Z84
5BX6
5BX7
5DH9
5LCP
5LCQ
5LCR
5LCT
5LCU
5M0B
5M0C
5M0L
5M0U
5M6V
5M6Y
5M71
5M75
5N23
5XOJ
6E21
6E99
6E9L
6FRX
6QJ7
6X2U
6X2V
6X2W
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?