ARFGAP1 and RPL11

Data Source:
BioGRID (two hybrid)

		ARFGAP1	RPL11
Description		ADP ribosylation factor GTPase activating protein 1	ribosomal protein L11
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GO Annotations	Cellular Component	Golgi Membrane Cytosol Synapse	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Polysomal Ribosome Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation RRNA Processing Translation Translational Initiation Protein Targeting SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Gene Expression Viral Transcription Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases			Diamond-Blackfan anemia (DBA)
GWAS
Interacting Genes		34 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	24 interacting genes: APP ARFGAP1 BLMH CAMK2B CDKN2A DVL3 GRWD1 HP HSPB2 IGF1R IP6K1 KRT40 KRTAP10-7 LIG4 MDM2 OSBPL3 PAIP2 PCAT1 PML SENP1 STAT3 TIGAR TP73 UBE2I
Entrez ID		55738	6135
HPRD ID		06443	10364
Ensembl ID		ENSG00000101199	ENSG00000142676
Uniprot IDs		Q53F62 Q8N6T3	P62913 Q5VVD0
PDB IDs		3DWD 3O47	4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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