PRKACB and TNP1

Data Source:
BioGRID (enzymatic study)

		PRKACB	TNP1
Description		protein kinase cAMP-activated catalytic subunit beta	transition protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base	Nucleosome Male Germ Cell Nucleus Nucleus
	Molecular Function	Magnesium Ion Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding	DNA Binding Protein Binding
	Biological Process	Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Protein Kinase A Signaling Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Negative Regulation Of Meiotic Cell Cycle Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Chromatin Silencing Multicellular Organism Development Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Positive Regulation Of Protein Processing Sexual Reproduction Flagellated Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Spermatogenesis, Exchange Of Chromosomal Proteins Negative Regulation Of Transcription, DNA-templated
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		Phosphonothreonine Fostamatinib
Diseases
GWAS		Breast cancer (male) ( 23001122) Metabolite levels ( 23823483)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010) Height ( 25282103 31562340) Hypothyroidism ( 27182965) Mitral valve prolapse ( 26301497) Permanent tooth development ( 21931568) Pulse pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73	10 interacting genes: CSNK2A1 DVL3 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2
Entrez ID		5567	7141
HPRD ID		01482	01830
Ensembl ID		ENSG00000142875	ENSG00000118245
Uniprot IDs		A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694	P09430 Q4ZG82
PDB IDs
Enriched GO Terms of Interacting Partners?
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