NPLOC4 and UFD1

Data Source:
HPRD (two hybrid)

		NPLOC4	UFD1
Description		NPL4 homolog, ubiquitin recognition factor	ubiquitin recognition factor in ER associated degradation 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process
Pathways		Translesion Synthesis by POLH	Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Refractive astigmatism ( 30306274) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 UBC UFD1 VPS26B	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP
Entrez ID		55666	7353
HPRD ID		06975	06778
Ensembl ID		ENSG00000182446	ENSG00000070010
Uniprot IDs		A0A024R8R4 Q8TAT6	Q541A5 Q92890
PDB IDs			2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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