NPLOC4 and GZMK

Data Source:
BioGRID (enzymatic study)

		NPLOC4	GZMK
Description		NPL4 homolog, ubiquitin recognition factor	granzyme K
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network	Extracellular Region
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis	Proteolysis
Pathways		Translesion Synthesis by POLH
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Refractive astigmatism ( 30306274) Refractive error ( 32231278)	Blood protein levels ( 30072576 29875488)
Interacting Genes		8 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 UBC UFD1 VPS26B	13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP
Entrez ID		55666	3003
HPRD ID		06975	02872
Ensembl ID		ENSG00000182446	ENSG00000113088
Uniprot IDs		A0A024R8R4 Q8TAT6	P49863
PDB IDs			1MZA 1MZD
Enriched GO Terms of Interacting Partners?
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