PRPF40A and DAAM1

Data Source:
BioGRID (two hybrid)

		PRPF40A	DAAM1
Description		pre-mRNA processing factor 40 homolog A	dishevelled associated activator of morphogenesis 1
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GO Annotations	Cellular Component	Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Stress Fiber Cytosol Plasma Membrane Membrane Motile Cilium Ciliary Basal Body
	Molecular Function	RNA Binding Protein Binding	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	Actin Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		mRNA Splicing - Major Pathway	PCP/CE pathway RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inferior temporal gyrus volume ( 31530798) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Parietal lobe volume ( 31396565) Parkinsonism in frontotemporal lobe dementia ( 29724592) Type 2 diabetes ( 25483131)
Interacting Genes		130 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 C4orf45 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	6 interacting genes: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA
Entrez ID		55660	23002
HPRD ID		10995	09433
Ensembl ID		ENSG00000196504	ENSG00000100592
Uniprot IDs		O75400	Q9Y4D1
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS	2J1D 2Z6E
Enriched GO Terms of Interacting Partners?
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