DAAM1 and DVL1

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		DAAM1	DVL1
Description		dishevelled associated activator of morphogenesis 1	dishevelled segment polarity protein 1
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GO Annotations	Cellular Component	Stress Fiber Cytosol Plasma Membrane Membrane Motile Cilium Ciliary Basal Body	Cytosol Microtubule Postsynaptic Density Lateral Plasma Membrane Clathrin-coated Vesicle Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Wnt Signalosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Molecular_function Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Actin Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway	Regulation Of Neurotransmitter Levels Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Presynapse Assembly Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		PCP/CE pathway RHO GTPases Activate Formins	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inferior temporal gyrus volume ( 31530798) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Parietal lobe volume ( 31396565) Parkinsonism in frontotemporal lobe dementia ( 29724592) Type 2 diabetes ( 25483131)	Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA	43 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 HDHD2 HECW1 KLHL12 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 TRIM69 USP13 VANGL1 VANGL2
Entrez ID		23002	1855
HPRD ID		09433	03220
Ensembl ID		ENSG00000100592	ENSG00000107404
Uniprot IDs		Q9Y4D1	O14640
PDB IDs		2J1D 2Z6E	6TTK
Enriched GO Terms of Interacting Partners?
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