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PRPF40A and FASLG
Data Source:
HPRD
(in vivo)
PRPF40A
FASLG
Description
pre-mRNA processing factor 40 homolog A
Fas ligand
Image
GO Annotations
Cellular Component
Nucleoplasm
U1 SnRNP
Membrane
Nuclear Matrix
Nuclear Speck
U2-type Prespliceosome
Extracellular Region
Extracellular Space
Nucleus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Molecular Function
RNA Binding
Protein Binding
Signaling Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Biological Process
MRNA Splicing, Via Spliceosome
Cytoskeleton Organization
Cell Cycle
Regulation Of Cell Shape
Cell Migration
Regulation Of Cytokinesis
MRNA Cis Splicing, Via Spliceosome
Cell Division
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Cell Apoptotic Process
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Cellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum
Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
mRNA Splicing - Major Pathway
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes
TNFs bind their physiological receptors
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Heel bone mineral density (
30598549
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Metabolite levels (
23823483
)
Pulse pressure (
30224653
)
Refractive error (
32231278
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic sensitization (
30013184
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
24999842
)
Crohn's disease (
21102463
23128233
)
Daytime sleep phenotypes (
27126917
)
Itch intensity from mosquito bite (
28199695
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
28714469
)
Vitiligo (
27723757
)
Interacting Genes
130 interacting genes:
ABI1
AKAP8L
APBB1IP
ARFGEF2
ASXL2
ATAD3A
BAG6
BEND7
BRD4
C4orf45
CAP2
CCNL1
CCT2
CCT4
CCT7
CDK12
CDK13
CHD3
CHERP
CPSF6
CT45A1
CUL1
CYFIP1
CYFIP2
DAAM1
DDIT4L
DHX15
DHX8
DHX9
DIAPH1
DZIP1
DZIP1L
ENAH
ERG
EVL
FASLG
FMN1
FMNL1
FMNL2
FMNL3
FN1
FNBP4
FRA10AC1
GAPDH
HIPK1
HNRNPF
HNRNPK
HNRNPU
HNRNPUL1
HSPB1
HSPG2
HTT
IL1RAP
KMT2B
LARP7
LTBP3
MAP1LC3A
MECP2
MMP11
NCKAP1L
NKAP
NKAPD1
NONO
PCBP2
PDCD7
PECAM1
PFKL
PIAS1
PIAS3
PIAS4
PICK1
PPIG
PRKAR1A
PSG5
PTPRF
RBM39
RBMX2
RCC2
RLF
RPL4
RPLP0
SDCBP
SDCBP2
SDK1
SERPINB9
SF1
SF3A1
SF3A2
SF3A3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SMAD4
SNIP1
SNRNP70
SON
SREK1
SREK1IP1
SRPK2
STIM2
TCEAL9
U2AF1
U2AF2
U2SURP
UBE2I
UBE2K
UBQLN1
UBQLN2
UBQLN4
UBR4
VASP
VCL
WAS
WASF2
WASL
WBP11
WBP4
WIPF1
XRCC6
YBX1
YLPM1
YWHAG
ZCCHC10
ZCCHC8
ZFHX3
ZHX1
ZNF341
ZNF451
82 interacting genes:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
CYSRT1
DAXX
DLG2
DMD
DNMBP
DOCK4
ECM1
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB1
FYN
GRAP
GRAP2
GRB2
HCK
IHO1
ITK
ITSN2
KALRN
KMT2A
KRT33B
KRT40
KRTAP11-1
KRTAP12-3
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NLA
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SEC23A
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TNS2
TRIP6
YES1
Entrez ID
55660
356
HPRD ID
10995
00610
Ensembl ID
ENSG00000196504
ENSG00000117560
Uniprot IDs
O75400
P48023
Q53ZZ1
PDB IDs
1UZC
1YWI
1YWJ
1ZR7
2CQN
2DYF
2KZG
2L5F
2L9V
2LKS
1BZI
4MSV
5L19
5L36
Enriched GO Terms of Interacting Partners
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