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PRPF40A and DHX9
Data Source:
BioGRID
(pull down)
PRPF40A
DHX9
Description
pre-mRNA processing factor 40 homolog A
DExH-box helicase 9
Image
GO Annotations
Cellular Component
Nucleoplasm
U1 SnRNP
Membrane
Nuclear Matrix
Nuclear Speck
U2-type Prespliceosome
Intracellular Anatomical Structure
Nucleus
Nucleoplasm
Perichromatin Fibrils
Nucleolus
Cytoplasm
Centrosome
Cytosol
Polysome
Actin Cytoskeleton
Membrane
RISC Complex
Nuclear Body
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Polysomal Ribosome
RISC-loading Complex
CRD-mediated MRNA Stability Complex
Nuclear Stress Granule
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
Regulatory Region RNA Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
Single-stranded RNA Binding
MRNA Binding
Protein Binding
ATP Binding
ATPase Activity
Nucleoside-triphosphatase Activity
Chromatin DNA Binding
3'-5' DNA/RNA Helicase Activity
3'-5' RNA Helicase Activity
SiRNA Binding
RNA Stem-loop Binding
3'-5' DNA Helicase Activity
Triplex DNA Binding
Metal Ion Binding
Nucleoside-triphosphate Diphosphatase Activity
Importin-alpha Family Protein Binding
RNA Polymerase Binding
RISC Complex Binding
Polysome Binding
Single-stranded 3'-5' DNA Helicase Activity
Sequence-specific MRNA Binding
Promoter-specific Chromatin Binding
Biological Process
MRNA Splicing, Via Spliceosome
Cytoskeleton Organization
Cell Cycle
Regulation Of Cell Shape
Cell Migration
Regulation Of Cytokinesis
MRNA Cis Splicing, Via Spliceosome
Cell Division
Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
DNA Replication
DNA-templated Transcription, Termination
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
RNA Secondary Structure Unwinding
Targeting Of MRNA For Destruction Involved In RNA Interference
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Protein-containing Complex Assembly
DNA-templated Viral Transcription
G-quadruplex DNA Unwinding
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Export From Nucleus
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Positive Regulation Of Viral Transcription
Regulation Of MRNA Processing
Regulation Of Defense Response To Virus By Host
Positive Regulation Of Inflammatory Response
MRNA Transport
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Response To Cytokine Stimulus
Pyroptosis
Small RNA Loading Onto RISC
CRD-mediated MRNA Stabilization
Cellular Response To Tumor Necrosis Factor
Cellular Response To Exogenous DsRNA
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Viral Translation
Positive Regulation Of Polysome Binding
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Positive Regulation Of Gene Silencing By MiRNA
Regulation Of Cytoplasmic Translation
Positive Regulation Of Cytoplasmic Translation
Pathways
mRNA Splicing - Major Pathway
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Heel bone mineral density (
30598549
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Metabolite levels (
23823483
)
Pulse pressure (
30224653
)
Refractive error (
32231278
)
Interacting Genes
130 interacting genes:
ABI1
AKAP8L
APBB1IP
ARFGEF2
ASXL2
ATAD3A
BAG6
BEND7
BRD4
C4orf45
CAP2
CCNL1
CCT2
CCT4
CCT7
CDK12
CDK13
CHD3
CHERP
CPSF6
CT45A1
CUL1
CYFIP1
CYFIP2
DAAM1
DDIT4L
DHX15
DHX8
DHX9
DIAPH1
DZIP1
DZIP1L
ENAH
ERG
EVL
FASLG
FMN1
FMNL1
FMNL2
FMNL3
FN1
FNBP4
FRA10AC1
GAPDH
HIPK1
HNRNPF
HNRNPK
HNRNPU
HNRNPUL1
HSPB1
HSPG2
HTT
IL1RAP
KMT2B
LARP7
LTBP3
MAP1LC3A
MECP2
MMP11
NCKAP1L
NKAP
NKAPD1
NONO
PCBP2
PDCD7
PECAM1
PFKL
PIAS1
PIAS3
PIAS4
PICK1
PPIG
PRKAR1A
PSG5
PTPRF
RBM39
RBMX2
RCC2
RLF
RPL4
RPLP0
SDCBP
SDCBP2
SDK1
SERPINB9
SF1
SF3A1
SF3A2
SF3A3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SMAD4
SNIP1
SNRNP70
SON
SREK1
SREK1IP1
SRPK2
STIM2
TCEAL9
U2AF1
U2AF2
U2SURP
UBE2I
UBE2K
UBQLN1
UBQLN2
UBQLN4
UBR4
VASP
VCL
WAS
WASF2
WASL
WBP11
WBP4
WIPF1
XRCC6
YBX1
YLPM1
YWHAG
ZCCHC10
ZCCHC8
ZFHX3
ZHX1
ZNF341
ZNF451
43 interacting genes:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
DUX4
EIF2AK2
ESR1
GEMIN2
GEMIN4
GTF2B
H2AX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
LINC01554
MBD2
NXF1
OGA
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
PTEN
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
Entrez ID
55660
1660
HPRD ID
10995
04386
Ensembl ID
ENSG00000196504
ENSG00000135829
Uniprot IDs
O75400
B3KU66
Q08211
PDB IDs
1UZC
1YWI
1YWJ
1ZR7
2CQN
2DYF
2KZG
2L5F
2L9V
2LKS
3LLM
3VYX
3VYY
Enriched GO Terms of Interacting Partners
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