PRPF40A and RPLP0

Data Source:
BioGRID (pull down)

		PRPF40A	RPLP0
Description		pre-mRNA processing factor 40 homolog A	ribosomal protein lateral stalk subunit P0
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GO Annotations	Cellular Component	Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Postsynapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Interleukin-12-mediated Signaling Pathway Cellular Response To Interleukin-4
Pathways		mRNA Splicing - Major Pathway	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		130 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 C4orf45 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	12 interacting genes: CCNDBP1 CSNK2A1 ERG GAS7 KRI1 PAFAH1B2 PPM1A PRPF40A PTEN SMAD3 STAU1 YWHAQ
Entrez ID		55660	6175
HPRD ID		10995	01610
Ensembl ID		ENSG00000196504	ENSG00000089157
Uniprot IDs		O75400	A0A024RBS2 P05388
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS	4V6W 4V6X 5AJ0 6OLG 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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