CFP and CFB

Data Source:
HPRD (in vitro)

		CFP	CFB
Description		complement factor properdin	complement factor B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Complement Binding Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Defense Response To Bacterium Neutrophil Degranulation	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation
Pathways		Alternative complement activation Activation of C3 and C5 Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins Neutrophil degranulation Regulation of Complement cascade	Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade
Drugs			Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency	Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS			Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		32 interacting genes: BANF2 C3 CFAP206 CFB CYSRT1 FHL5 FKBP6 GEMIN4 GNE HEXIM2 HOXA1 KCTD9 KLHL38 KRTAP11-1 KRTAP12-2 KRTAP3-1 KRTAP6-2 LCE1A LONRF1 MID2 MTOR NEK6 NOXA1 PRKAB2 RECK SMARCC1 SPAG8 STK16 TRIP13 VENTX ZNF330 ZNF414	5 interacting genes: C3 CFP LAMC3 LAMTOR5 RPA2
Entrez ID		5199	629
HPRD ID		02308	00718
Ensembl ID		ENSG00000126759	ENSG00000243649
Uniprot IDs		A0A0S2Z4I5 P27918	A0A1U9X7H8 P00751
PDB IDs		1W0R 1W0S 6RUR 6RUS 6RUV 6RV6 6S08 6S0A 6S0B 6SEJ	1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV 6T8U 6T8V 6T8W
Enriched GO Terms of Interacting Partners?
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