PRKAB1 and ACACA

Data Source:
BioGRID (enzymatic study)

		PRKAB1	ACACA
Description		protein kinase AMP-activated non-catalytic subunit beta 1	acetyl-CoA carboxylase alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Fibrillar Center Cytosol Actin Cytoskeleton
	Molecular Function	Protein Kinase Activity Protein Binding Protein Kinase Binding	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	Tissue Homeostasis Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis
Drugs		Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib	Biotin
Diseases
GWAS		Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)	Ovarian cancer ( 23535730)
Interacting Genes		12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2	11 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 PRKAA1 PRKAA2 PRKAB1 PRKAG1
Entrez ID		5564	31
HPRD ID		04116	01938
Ensembl ID		ENSG00000111725	ENSG00000278540
Uniprot IDs		A0A024RBN1 Q9Y478	A0A024R0Y2 Q13085 Q7Z5W8
PDB IDs		4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J	2YL2 3COJ 4ASI 6G2D 6G2H 6G2I
Enriched GO Terms of Interacting Partners?
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