PRKAB1 and AGL

Data Source:
HPRD (in vitro, in vivo)

		PRKAB1	AGL
Description		protein kinase AMP-activated non-catalytic subunit beta 1	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Kinase Activity Protein Binding Protein Kinase Binding	Glycogen Debranching Enzyme Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding Beta-maltose 4-alpha-glucanotransferase Activity
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Neutrophil Degranulation Response To Glucocorticoid
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)	Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2	3 interacting genes: APPL1 NHLRC1 PRKAB1
Entrez ID		5564	178
HPRD ID		04116	01984
Ensembl ID		ENSG00000111725	ENSG00000162688
Uniprot IDs		A0A024RBN1 Q9Y478	A0A0S2A4E4 P35573
PDB IDs		4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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