AGL and PRKAB1

Data Source:
HPRD (in vitro, in vivo)

		AGL	PRKAB1
Description		amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	protein kinase AMP-activated non-catalytic subunit beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Glycogen Debranching Enzyme Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding Beta-maltose 4-alpha-glucanotransferase Activity	Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Neutrophil Degranulation Response To Glucocorticoid	Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: APPL1 NHLRC1 PRKAB1	12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2
Entrez ID		178	5564
HPRD ID		01984	04116
Ensembl ID		ENSG00000162688	ENSG00000111725
Uniprot IDs		A0A0S2A4E4 P35573	A0A024RBN1 Q9Y478
PDB IDs			4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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