AGL and NHLRC1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		AGL	NHLRC1
Description		amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	NHL repeat containing E3 ubiquitin protein ligase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Glycogen Debranching Enzyme Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding Beta-maltose 4-alpha-glucanotransferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Neutrophil Degranulation Response To Glucocorticoid	Protein Polyubiquitination Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Localization To Plasma Membrane
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		3 interacting genes: APPL1 NHLRC1 PRKAB1	9 interacting genes: AGL EPM2A GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H
Entrez ID		178	378884
HPRD ID		01984	06995
Ensembl ID		ENSG00000162688	ENSG00000187566
Uniprot IDs		A0A0S2A4E4 P35573	Q6VVB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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