PREP and NTS

Data Source:
HPRD (in vitro)

		PREP	NTS
Description		prolyl endopeptidase	neurotensin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane	Extracellular Region Transport Vesicle Intracellular Membrane-bounded Organelle Axon Terminus
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Oligopeptidase Activity	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding
	Biological Process	Proteolysis	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)	Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1	10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		5550	4922
HPRD ID		02673	08878
Ensembl ID		ENSG00000085377	ENSG00000133636
Uniprot IDs		B2RAH7 P48147	P30990 Q6FH20
PDB IDs		3DDU	2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7
Enriched GO Terms of Interacting Partners?
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