PREP and OXT

Data Source:
HPRD (in vitro)

		PREP	OXT
Description		prolyl endopeptidase	oxytocin/neurophysin I prepropeptide
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane	Extracellular Region Extracellular Space Secretory Granule Terminal Bouton
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Oligopeptidase Activity	Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding Oxytocin Receptor Binding
	Biological Process	Proteolysis	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Sleep Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Prostaglandin E Social Behavior Negative Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Cocaine Hyperosmotic Salinity Response Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis
Pathways			Vasopressin-like receptors G alpha (q) signalling events
Drugs		1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione	Oxytocin
Diseases
GWAS		Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Serum oxytocin levels ( 31361301)
Interacting Genes		7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1	5 interacting genes: ESR2 KMT2A OXTR PREP TXNDC17
Entrez ID		5550	5020
HPRD ID		02673	08880
Ensembl ID		ENSG00000085377	ENSG00000101405
Uniprot IDs		B2RAH7 P48147	P01178 X5D7M6
PDB IDs		3DDU
Enriched GO Terms of Interacting Partners?
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