NTS and PREP

Data Source:
HPRD (in vitro)

		NTS	PREP
Description		neurotensin	prolyl endopeptidase
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GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Intracellular Membrane-bounded Organelle Axon Terminus	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Oligopeptidase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway	Proteolysis
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Metabolite levels ( 23823483)	Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1	7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1
Entrez ID		4922	5550
HPRD ID		08878	02673
Ensembl ID		ENSG00000133636	ENSG00000085377
Uniprot IDs		P30990 Q6FH20	B2RAH7 P48147
PDB IDs		2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7	3DDU
Enriched GO Terms of Interacting Partners?
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