PPP3CC and HAX1

Data Source:
BioGRID (two hybrid)

		PPP3CC	HAX1
Description		protein phosphatase 3 catalytic subunit gamma	HCLS1 associated protein X-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Presynapse Glutamatergic Synapse	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane
	Molecular Function	Protein Binding Calmodulin Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Protein Dephosphorylation Brain Development Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		14 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC PPP3R1 SDC2 SPATA33 TGFBR1 THAP7 UNC119	25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420
Entrez ID		5533	10456
HPRD ID		00236	12075
Ensembl ID		ENSG00000120910	ENSG00000143575
Uniprot IDs		P48454	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs
Enriched GO Terms of Interacting Partners?
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