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HAX1 and PKD2
Data Source:
HPRD
(in vivo, two hybrid)
HAX1
PKD2
Description
HCLS1 associated protein X-1
polycystin 2, transient receptor potential cation channel
Image
No pdb structure
GO Annotations
Cellular Component
P-body
Nuclear Envelope
Transcription Regulator Complex
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Cell Cortex
Actin Cytoskeleton
Apical Plasma Membrane
Sarcoplasmic Reticulum
Lamellipodium
Clathrin-coated Vesicle
Nuclear Membrane
Polycystin Complex
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cilium
Basal Plasma Membrane
Membrane
Lamellipodium
Cytoplasmic Vesicle Membrane
Motile Cilium
Filamentous Actin
Cation Channel Complex
Ciliary Basal Body
Basal Cortex
Ciliary Membrane
Extracellular Exosome
Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Mitotic Spindle
Non-motile Cilium
Molecular Function
Protein Binding
Interleukin-1 Binding
Protein N-terminus Binding
Signaling Receptor Binding
Voltage-gated Ion Channel Activity
Voltage-gated Calcium Channel Activity
Voltage-gated Sodium Channel Activity
Voltage-gated Potassium Channel Activity
Cation Channel Activity
Calcium Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Outward Rectifier Potassium Channel Activity
Voltage-gated Cation Channel Activity
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
HLH Domain Binding
Ion Channel Binding
Calcium-induced Calcium Release Activity
ATPase Binding
Phosphoprotein Binding
Muscle Alpha-actinin Binding
Biological Process
Mitochondrion Organization
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Actin Cytoskeleton Reorganization
Branching Involved In Ureteric Bud Morphogenesis
Liver Development
Embryonic Placenta Development
Heart Looping
Detection Of Nodal Flow
Calcium Ion Transport
Cell Cycle Arrest
Receptor Signaling Pathway Via JAK-STAT
Determination Of Left/right Symmetry
Heart Development
Negative Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Spinal Cord Development
Neural Tube Development
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Cellular Response To Reactive Oxygen Species
Metanephric Part Of Ureteric Bud Development
Sodium Ion Transmembrane Transport
Aorta Development
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Cilium Organization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Release Of Sequestered Calcium Ion Into Cytosol
Protein Tetramerization
Protein Homotetramerization
Protein Heterotetramerization
Centrosome Duplication
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Placenta Blood Vessel Development
Renal Tubule Morphogenesis
Renal Artery Morphogenesis
Calcium Ion Transmembrane Transport
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Hydrostatic Pressure
Cellular Response To Osmotic Stress
Cellular Response To Fluid Shear Stress
Potassium Ion Transmembrane Transport
Determination Of Liver Left/right Asymmetry
Metanephric Mesenchyme Development
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Smooth Muscle Tissue Development
Metanephric Cortex Development
Metanephric Ascending Thin Limb Development
Metanephric Cortical Collecting Duct Development
Metanephric Distal Tubule Development
Metanephric S-shaped Body Morphogenesis
Regulation Of Calcium Ion Import
Inorganic Cation Transmembrane Transport
Cell-cell Signaling By Wnt
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
Drugs
Diseases
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
Polycystic kidney disease
GWAS
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
Mean spheric corpuscular volume (
32888494
)
Nicotine dependence (
28440896
)
Non-albumin protein levels (
29403010
)
Reticulocyte count (
32888494
)
Serum total protein level (
29403010
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Coffee consumption (cups per day) (
25288136
)
Dental caries (
23064961
)
Gout (
30899057
)
Hyperuricemia (
28776340
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Uric acid levels (
29558500
)
Interacting Genes
25 interacting genes:
ABCB1
ABCB11
ABCB4
BIRC3
CTTN
DGKD
EIF3F
HCLS1
HNF4G
IL1A
KIAA0513
MAPK10
NEDD4L
PKD2
POLR1D
POLR1H
PPP3CC
PRNP
RBX1
RNF217
RPA1
STAT5B
SVIL
YWHAQ
ZNF420
21 interacting genes:
ACTN2
CD2AP
CYSRT1
DIAPH1
HAX1
HSF2BP
KRT40
KRTAP10-3
KRTAP10-8
KRTAP6-2
LMNA
MAGEA8
MDFI
PACS1
PACS2
PKD1
PLSCR1
PTPRG
TNNI3
TPM1
TRPC1
Entrez ID
10456
5311
HPRD ID
12075
01437
Ensembl ID
ENSG00000143575
ENSG00000118762
Uniprot IDs
A0A0S2Z565
A0A0S2Z591
O00165
Q13563
Q9UEU6
PDB IDs
2KLD
2KLE
2KQ6
2Y4Q
3HRN
3HRO
5K47
5MKE
5MKF
5T4D
6A70
6D1W
6T9N
6T9O
6WB8
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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