HAX1 and ABCB1

Data Source:
HPRD (two hybrid, in vivo)

		HAX1	ABCB1
Description		HCLS1 associated protein X-1	ATP binding cassette subfamily B member 1
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane	Nucleoplasm Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome External Side Of Apical Plasma Membrane
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATPase Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity Floppase Activity
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	G2/M Transition Of Mitotic Cell Cycle Response To Drug Phospholipid Translocation Terpenoid Transport Regulation Of Response To Osmotic Stress Transmembrane Transport Transepithelial Transport Stem Cell Proliferation Ceramide Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Positive Regulation Of Anion Channel Activity Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier Regulation Of Chloride Transport
Pathways			Abacavir transmembrane transport ABC-family proteins mediated transport
Drugs			ATP Medroxyprogesterone acetate Roxithromycin Fentanyl Voacamine Elacridar Tesmilifene FM-VP4 Zosuquidar Tariquidar Miltefosine Tocofersolan Hycanthone Concanamycin A Dexverapamil Emopamil Lomerizine Tetrandrine Dofequidar Dexniguldipine ONT-093 HM-30181 Desmethylsertraline Reversin 121
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Bone mineral density (spine) and age at menarche ( 26312577) Gallbladder cancer ( 28274756) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420	11 interacting genes: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2
Entrez ID		10456	5243
HPRD ID		12075	01370
Ensembl ID		ENSG00000143575	ENSG00000085563
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	A4D1D2 P08183
PDB IDs			6C0V 6FN1 6FN4 6QEX 7A65 7A69 7A6C 7A6E 7A6F
Enriched GO Terms of Interacting Partners?
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