HAX1 and ABCB11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HAX1	ABCB11
Description		HCLS1 associated protein X-1	ATP binding cassette subfamily B member 11
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Intercellular Canaliculus Intracellular Canaliculus Recycling Endosome Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	Transporter Activity Protein Binding ATP Binding P-type Sodium Transporter Activity ABC-type Xenobiotic Transporter Activity Bile Acid Transmembrane Transporter Activity Canalicular Bile Acid Transmembrane Transporter Activity ABC-type Bile Acid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Fatty Acid Metabolic Process Bile Acid Biosynthetic Process Drug Transmembrane Transport Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Protein Ubiquitination Drug Metabolic Process Regulation Of Fatty Acid Beta-oxidation Sodium Ion Transmembrane Transport Cholesterol Homeostasis Xenobiotic Transport Drug Export Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Positive Regulation Of Bile Acid Secretion Regulation Of Bile Acid Metabolic Process
Pathways			Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes PFIC2 and BRIC2
Drugs			ATP Glyburide
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Gamma glutamyl transferase levels ( 29403010) Glycated hemoglobin levels ( 24647736 20858683 31213470 29170429) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 21909109) Red cell distribution width ( 32888494) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420	4 interacting genes: DDIT4L HAX1 LY6D NR4A1
Entrez ID		10456	8647
HPRD ID		12075	04436
Ensembl ID		ENSG00000143575	ENSG00000073734
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	O95342
PDB IDs			6LR0
Enriched GO Terms of Interacting Partners?
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