HAX1 and HCLS1

Data Source:
HPRD (in vitro, two hybrid)

		HAX1	HCLS1
Description		HCLS1 associated protein X-1	hematopoietic cell-specific Lyn substrate 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Site Of Polarized Growth Cortical Actin Cytoskeleton
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	RNA Polymerase II Transcription Factor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420	24 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		10456	3059
HPRD ID		12075	03199
Ensembl ID		ENSG00000143575	ENSG00000180353
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	P14317
PDB IDs
Enriched GO Terms of Interacting Partners?
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