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HAX1 and HCLS1
Data Source:
HPRD
(in vitro, two hybrid)
HAX1
HCLS1
Description
HCLS1 associated protein X-1
hematopoietic cell-specific Lyn substrate 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
P-body
Nuclear Envelope
Transcription Regulator Complex
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Cell Cortex
Actin Cytoskeleton
Apical Plasma Membrane
Sarcoplasmic Reticulum
Lamellipodium
Clathrin-coated Vesicle
Nuclear Membrane
Nucleus
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Actin Filament
Plasma Membrane
Site Of Polarized Growth
Cortical Actin Cytoskeleton
Molecular Function
Protein Binding
Interleukin-1 Binding
Protein N-terminus Binding
RNA Polymerase II Transcription Factor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Actin Filament Binding
Biological Process
Mitochondrion Organization
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Response To Hormone
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Filament Polymerization
Erythrocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Negative Regulation Of Leukocyte Apoptotic Process
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs
Diseases
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
Mean spheric corpuscular volume (
32888494
)
Nicotine dependence (
28440896
)
Non-albumin protein levels (
29403010
)
Reticulocyte count (
32888494
)
Serum total protein level (
29403010
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Interacting Genes
25 interacting genes:
ABCB1
ABCB11
ABCB4
BIRC3
CTTN
DGKD
EIF3F
HCLS1
HNF4G
IL1A
KIAA0513
MAPK10
NEDD4L
PKD2
POLR1D
POLR1H
PPP3CC
PRNP
RBX1
RNF217
RPA1
STAT5B
SVIL
YWHAQ
ZNF420
24 interacting genes:
ACTA1
ACTR2
ACTR3
BLZF1
CASP3
CD79A
CSNK2A1
FGR
GRB2
HAX1
HS1BP3
IKBKG
LYN
LZTR1
MAP4K1
QKI
SH2D4A
SH3BP2
SSBP3
SYK
TERF1
TRIM29
WAS
ZBTB25
Entrez ID
10456
3059
HPRD ID
12075
03199
Ensembl ID
ENSG00000143575
ENSG00000180353
Uniprot IDs
A0A0S2Z565
A0A0S2Z591
O00165
P14317
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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