FBXW7 and SHPRH

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FBXW7	SHPRH
Description		F-box and WD repeat domain containing 7	SNF2 histone linker PHD RING helicase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleosome Nucleoplasm
	Molecular Function	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Protein Polyubiquitination DNA Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Protein Ubiquitination
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		77 interacting genes: AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 EBNA1BP2 EXT1 EZH2 FANCC FBP1 FBP2 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SEC61B SHC1 SHPRH SKP1 SMAD1 SOX9 SREBF1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TP53 TSC22D4 USP9X WDR97 XPA ZNF510	10 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG
Entrez ID		55294	257218
HPRD ID		05888	10476
Ensembl ID		ENSG00000109670	ENSG00000146414
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	B3KX98 Q149N8
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B	2M85 4QN1
Enriched GO Terms of Interacting Partners?
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