SHPRH and EDARADD

		SHPRH	EDARADD
Description		SNF2 histone linker PHD RING helicase	EDAR associated death domain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleoplasm	Cytosol
	Molecular Function	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Protein Ubiquitination	Multicellular Organism Development Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS			Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		10 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I
Entrez ID		257218	128178
HPRD ID		10476	05965
Ensembl ID		ENSG00000146414	ENSG00000186197
Uniprot IDs		B3KX98 Q149N8	Q8WWZ3
PDB IDs		2M85 4QN1
Enriched GO Terms of Interacting Partners?
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