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FBXW7 and CCDC6
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
FBXW7
CCDC6
Description
F-box and WD repeat domain containing 7
coiled-coil domain containing 6
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
SCF Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Cytosol
Cytoskeleton
Molecular Function
Protein Binding
Cyclin Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Binding
Phosphothreonine Residue Binding
Ubiquitin-protein Transferase Activator Activity
Structural Constituent Of Cytoskeleton
Protein Binding
SH3 Domain Binding
Identical Protein Binding
Biological Process
Protein Polyubiquitination
Vasculogenesis
Vasculature Development
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Ubiquitin Recycling
Viral Process
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of Protein Localization
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Rhythmic Process
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Osteoclast Development
Cytoskeleton Organization
Biological_process
Pathways
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Thyroid cancer
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Alopecia areata (
25608926
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Interacting Genes
77 interacting genes:
AHSG
AKT1
ANGPTL4
ANP32B
ARL6IP1
BCAS3
BEX1
BLM
CCDC6
CCNE1
CCNE2
CDC34
CEBPD
CUL1
DISC1
DVL1
EBNA1BP2
EXT1
EZH2
FANCC
FBP1
FBP2
GALNT12
GATA2
GATA3
GFI1
GLMN
HEMGN
HEY1
HIPK2
HNRNPK
HRAS
IGFBP3
IL24
JUN
KLF10
KLF5
LINGO1
MAP2K1
MAPK3
MMS22L
MYB
MYC
MYCN
NANS
NOTCH1
NOTCH4
NPM1
PLK1
PPARGC1A
PPP3R2
PRKN
PSEN1
PTPN11
RACK1
RFLNA
SCGB3A1
SEC61B
SHC1
SHPRH
SKP1
SMAD1
SOX9
SREBF1
STAT3
STAT5A
STOML1
STYX
SUMF2
TGFB1
TMOD1
TP53
TSC22D4
USP9X
WDR97
XPA
ZNF510
32 interacting genes:
ATF2
ATF5
CCDC136
CCDC33
CENPQ
CREB1
CSNK2A1
CYTH4
FBXW7
GAS8
LHX3
LRSAM1
LUZP4
MAPK3
MAPK7
MEOX2
MTUS2
PAX6
PIN1
PPP4C
SH3RF1
SNAPC1
SORBS3
TFIP11
TRIM14
UBE2I
WAC
ZNF250
ZNF354C
ZNF620
ZNF774
ZNF835
Entrez ID
55294
8030
HPRD ID
05888
09064
Ensembl ID
ENSG00000109670
ENSG00000108091
Uniprot IDs
G0Z2K0
Q969H0
S4R3U4
Q05CP8
Q16204
PDB IDs
2OVP
2OVQ
2OVR
5IBK
5V4B
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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