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FBXW7 and CCNE1
Data Source:
HPRD
(in vivo, in vitro)
FBXW7
CCNE1
Description
F-box and WD repeat domain containing 7
cyclin E1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
SCF Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cyclin E1-CDK2 Complex
Molecular Function
Protein Binding
Cyclin Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Binding
Phosphothreonine Residue Binding
Ubiquitin-protein Transferase Activator Activity
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Biological Process
Protein Polyubiquitination
Vasculogenesis
Vasculature Development
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Ubiquitin Recycling
Viral Process
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of Protein Localization
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Rhythmic Process
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Osteoclast Development
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
DNA Replication Initiation
Protein Phosphorylation
Homologous Chromosome Pairing At Meiosis
Wnt Signaling Pathway
Mitotic Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of Cellular Protein Localization
Pathways
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
PTK6 Regulates Cell Cycle
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
RHOBTB3 ATPase cycle
Drugs
Diseases
Laryngeal cancer
Gastric cancer
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Adult body size (
32376654
)
Bladder cancer (
24163127
20972438
)
Body mass index (
25673413
)
Breast cancer (
29058716
)
Breast cancer (estrogen-receptor negative) (
29058716
)
Diastolic blood pressure (
28135244
27841878
)
Medication use (diuretics) (
31015401
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Spatial processing (
31596458
)
Interacting Genes
77 interacting genes:
AHSG
AKT1
ANGPTL4
ANP32B
ARL6IP1
BCAS3
BEX1
BLM
CCDC6
CCNE1
CCNE2
CDC34
CEBPD
CUL1
DISC1
DVL1
EBNA1BP2
EXT1
EZH2
FANCC
FBP1
FBP2
GALNT12
GATA2
GATA3
GFI1
GLMN
HEMGN
HEY1
HIPK2
HNRNPK
HRAS
IGFBP3
IL24
JUN
KLF10
KLF5
LINGO1
MAP2K1
MAPK3
MMS22L
MYB
MYC
MYCN
NANS
NOTCH1
NOTCH4
NPM1
PLK1
PPARGC1A
PPP3R2
PRKN
PSEN1
PTPN11
RACK1
RFLNA
SCGB3A1
SEC61B
SHC1
SHPRH
SKP1
SMAD1
SOX9
SREBF1
STAT3
STAT5A
STOML1
STYX
SUMF2
TGFB1
TMOD1
TP53
TSC22D4
USP9X
WDR97
XPA
ZNF510
70 interacting genes:
AKT1
AR
ARHGEF5
ARID4A
ARIH1
ARNT
AURKA
BRCA2
BTRC
CABLES1
CALM1
CCND2
CCT4
CDC25A
CDC6
CDK1
CDK2
CDK3
CDK4
CDK6
CDKN1A
CDKN1B
CDKN2A
CDKN2B
CDKN2C
COIL
CUL3
FBXW7
FGFR4
FOXM1
FZR1
GLIS2
GMNC
GRM1
GSK3B
H1-0
H1-1
H1-5
HERC5
KAT2A
LATS2
MARCKS
MCM3
MRE11
MYBL2
MYC
NBN
NF2
PIN1
POLD1
PRC1
PRKAR1A
PTPA
RASSF1
RB1
RBL1
RBL2
REL
RHOBTB3
RRN3
SKP2
SMARCA4
SMARCC1
SMARCD3
SPOP
STK11
TERT
TP73
TSC1
UBTF
Entrez ID
55294
898
HPRD ID
05888
00455
Ensembl ID
ENSG00000109670
ENSG00000105173
Uniprot IDs
G0Z2K0
Q969H0
S4R3U4
A0A0G3DHS8
P24864
V5W5X2
PDB IDs
2OVP
2OVQ
2OVR
5IBK
5V4B
1W98
5L2W
Enriched GO Terms of Interacting Partners
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